The Formula Composed of Chlorogenic Acid and Total Lignans From Fructus Arctii has Stronger Hypoglycemic Effect on Kkay Mice Than When They are Used Alone
Tong Jin2, Huating Zhang1, Jingyun Zhang1, Haiying Wang2*and Zhaohui Xu1*
1Innovative Chinese Medicine Research Institute, Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China
2School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China
Fructus Arctii, the dried ripe fruit of Arctium lappa L. has been used to treat diabetes since ancient times in China. Total lignans from Fructus Arctii (TLFA) and chlorogenic acid (3-O caffeoylquinic acid, CA) are the main components of it, which have been reported to have hypoglycemic activity respectively. In this study, they were combined according to several content ratios that different from the ratio they exist in Fructus Arctii, for obtaining stronger hypoglycemic effect. KKAy mice, a spontaneous Type 2 diabetic model were gavaged once daily with the experimentaldrugs for 6 weeks. The result indicates that when CA and TLFA were used alone, their hypoglycemic effect were lower than that of metformin. However, when they are used in combination, their hypoglycemic effect has been greatly strengthened, and the effect of the formula is not a simple addition of the activities of the two substances.