Asian Journal of Complementary and Alternative Medicine

The Controversy: Whether Sucralose Could Increase Blood Glucose in The Body?

Mengqiu Li^1#, Ziyang Lin^1#, Minyi Li¹, Yongjin Zhu³, Tingting Duan¹, Lanqing Meng¹, Xianlong Zhang^1,2, Tao Xia1, Guixuan Lin¹, Xiuqing Lu¹, Zhenghai Li¹ and Junzheng Yang¹*

¹Guangdong nephrotic drug Engineering Technology Research Center, Institute of Consun Co. for Chinese Medicine in Kidney Diseases, Guangdong Consun Pharmaceutical Group, Guangzhou, China
²The Second Clinical College, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, China
³Guangzhou Baiyun District Third People’s Hospital, Guangzhou, China

Abstract

Sucralose is the most used artificial sweetener around the world, accounted for 30% of the global low-calorie sweetener market in 2016. According to the inspection of 19915 pre-packaged foods in Hong Kong, sucralose is the most used non-nutritive sweetener, followed by acesulfame. In addition to the food industry, sucralose can also be used as one kind of subsidiary materials for correcting taste in suspension agent, oral liquid, tablets, and granules, which could cover up the bitter taste of medicines such as aspirin or traditional Chinese medicine compound. The Food and Drug Administration (FDA) had approved the use of sucralose, but whether sucralose intake has effect on blood glucose is not clarified clearly. For this purpose, we collected and summarized the clinical studies to evaluate the effect of sucralose intake on blood glucose since 1996 from PubMed database, hope it may provide some evidence for sucralose applications in food excipient or drug sweet excipient.

Keywords:

Sucralose, sweetener, blood glucose, sweet excipient