Asian Journal of Complementary and Alternative Medicine

Role of Ayurvedic plants in prevention and management of Senile Dementia of Alzheimer’s type: A Review

Padmini Mishra¹, Aruna Agrawal²,. Priyanka Purohit² and G.P. Dubey¹

¹Research fellow collaborative program, Faculty of Ayurveda

Institute of Medical Sciences, B.H.U.

Varanasi (U.P) 221005: INDIA

²Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi - 221 005, India.

Abstract

Senile dementia is one of the age associated, irreversible, mental problem characteristic symptoms of various neurodegenerative diseases. It is considered as the most common form of dementia and it is observed that people over the age of 70 years suffers from a significant memory loss. It includes forgetfulness, difficulty in performing routine task, acetylcholine deficiency and inflammation of brain tissue. Although there is no cure for Alzheimer’s disease but drugs are designed to delay the progression of disease. Various biomarkers has been well established which diagnose the Alzheimer’s disease. Medicinal plants have been used for the development of drugs, almost 100 new products are already in clinical development .This review gathers various medicinal plants and their constituents, have been used in traditional system of medicine for treatment of cognitive impairment. Plants such as curcuma longa, bacopa monneri, hippophae rhamnoides, centella asiatica and ginkgo biloba are used in the prevention and treatment of Alzheimer’s disease and various biomarkers are also discussed.

Keywords:

Alzheimer’s disease, senile dementia, amyloid peptide, antioxidant activity, anti inflammatory, loss of memory.