Sucralose is the most used artificial sweetener around the world, accounted for 30% of the global low-calorie sweetener market in 2016. According to the inspection of 19915 pre-packaged foods in Hong Kong, sucralose is the most used non-nutritive sweetener, followed by acesulfame. In addition to the food industry, sucralose can also be used as one kind of subsidiary materials for correcting taste in suspension agent, oral liquid, tablets, and granules, which could cover up the bitter taste of medicines such as aspirin or traditional Chinese medicine compound. The Food and Drug Administration (FDA) had approved the use of sucralose, but whether sucralose intake has effect on blood glucose is not clarified clearly. For this purpose, we collected and summarized the clinical studies to evaluate the effect of sucralose intake on blood glucose since 1996 from PubMed database, hope it may provide some evidence for sucralose applications in food excipient or drug sweet excipient.