As a common ocular surface disease in ophthalmology clinics, dry eye has been perplexing the medical field due to its complex pathogenesis. Therefore, early detection and early treatment are particularly important. The author found in the course of clinical treatment that if dry eye goes untreated and becomes refractory dry eye, eyelash weakness and difficulty in opening eyes will occur; Meige syndrome (MG) has not been reported in the literature, but it appears now The introduction of these two rare diseases, hoping to attract the attention of clinicians, so as to prevent the passing of time and avoid more serious complications.