Evaluation of in vivo wound healing and anti-inflammatory activity of 80% methanolic extract of the leaves of B. antidysentrica J. F. Mill (Simaroubaceae) in mice

Zenaw Tessema1, Eyasu Makonnen2, Asfaw Debella3, Desalegn Yibeltal4 and Yalew Molla5

Abstract

Objective: The purpose of this study was to evaluate the wound healing and anti-inflammatory activities of the crude extract of the leaves of B. antidysentrica J. F. Mill.

Results: Both 2% and 4% crude extract revealed significant wound healing activity compared with negative control as evidenced by an increase in the percent of wound contraction (p < 0.01) and a decrease in epithelization period (p<0.05). In addition, both 2% and 4% extract ointments resulted in a significant increase in tensile strength (p < 0.01) compared with negative control. Hundred, two hundred and four hundred mg/kg extracts of the leaves exhibited a higher anti-inflammatory effect on the 3rd (P<0.05) and 4th hour (P<0.001) as compared to the negative control.

Keywords

B. antidysentrica J. F. Mill, wound healing, anti-inflammatory, excision, incision