Whole plant of Phyllanthus niruri Linn. (Euphorbiaceae) were screened for adaptogenic activity using Swim Endurance model and Cold Stress model. Ethyl acetate extract as well as Pet ether (40-60oC) and 70% ethanol extracts showed significant adaptogenic activity when administered orally at a dose of 200 mg/kg body weight . The extracts significantly increased the active swim endurance time. Stress induced animals exhibited hyperglycemia as well as depletion in triglyceride level, increased total leukocyte count and restored the organ weights. The extracts showed a significant action in overcoming these imbalances. It was also found that extracts proved efficient in controlling the hyperlipidemic condition due to stress.