Therapeutic effect of eel serum in an experimental rat model of chronic kidney failure
Luis Bárcenas-García, Clemente Vásque Miguel Huerta-Viera, Raúl López-Ascencio, Mario Del Toro-Equihua
Institute of Medical Sciences BHU, Varanasi Uttar Pradesh, INDIA
Background: Chronic kidney failure causes deficits in glomerular filtration. Although it has been reported that eel serum stops this deficit, the specific mechanisms are unknown.
Objective: To determine whether eel serum improves creatinine clearance in a rat model of chronic kidney failure.
Methods: 40 rats were divided into 4 groups. Three groups received eel serum (at 1x10-1 %, 1X10-4 % and 1x10-7 %, in a volume of 0.5 ml) and one received the vehicle (control), all for a period of 2.5 months.
Setting: Laboratory of University of Colima´s Faculty of Medicine.
Primary Outcome Measures: Significant change in creatinine clearance.
Results: With two of the doses of eel serum (1x10ˉ¹ % and 1x10-7 %) there was no significant change in creatinine clearance. However, with 1x10-4 % of eel serum the creatinine clearance in rats decreased only 0.2%, whereas an 18% decrease in this parameter was found in the control group.
Conclusion: With a dose of 1x10-4 % of eel serum, there was a significant detention in the normal continuous drop in creatinine clearance in a rat model of chronic kidney failure.