Terminalia chebula attenuates ischemia reperfusion induced progressive nephropathy in diabetic rats
Narendra Silawat1*, Vipin Bihari Gupta2
1 Research Scholar, Faculty of Pharmaceutical Sciences, Jodhpur National University, Jodhpur (Rajasthan)
2 Director, B. R. Nahata College of Pharmacy, Mandsaur (Madhya Pradesh)
Terminalia chebula is called as "king of medicines" in ayurveda and has been used traditionally to treat various diseases. Ischemia causes rapid progressive nephropathy in diabetic rats. The present study was undertaken to investigate the effect of T chebula on unilateral ischemia induced renal damage in diabetic rats. The 4 week treatment with ethanolic extract of T chebula fruit (200 mg/kg & 400 mg/kg) showed reduction in damage caused by ischemia; decreased oxidative stress and improved renal histological appearance of kidney section. From results it was concluded that T chebula attenuates the renal damage caused by ischemia and can be beneficial in diabetic nephropathy.
Diabetic nephropathy, ischemia & reperfusion, Terminalia chebula.