Asian Journal of Complementary and Alternative Medicine

Reveal the Relationship Between Hyaluronic Acid and Water Using Aquaphotomics

Weilu Tian¹, Qin Dong¹, Boran Lin¹, Xiangchun Yang¹, Hui Zhang¹, Lian Li¹, Lei Nie¹, Xueping Guo², Siling Huang², Hengchang Zang^1*

¹School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, PR China

²Bloomage Biotechnology Corporation Limited, Jinan, Shandong, PR China

Abstract

Hyaluronic acid (HA) is a kind of biological macromolecule with strong water binding ability. It has rich biological functions and plays an important role in the living body. It has extremely high application value in the fields of medical beauty, medicine, medical treatment and food. In the past, the thinking of studying HA was rather rigid, which is reflected in the direct study of HA itself, which is quite difficult in a complex system because there are too many influencing factors in the real biological environment. The proposal of aquaphotomics allows researchers to focus on the water molecules in complex biological systems, which leads us to shift the angle of thinking about HA-related issues to the water molecules that are closely bound to it. In previous and ongoing work, we use spectroscopy technology and aquaphotomics to study water species, focus on the widely used HA and its  erivatives
on the market, and apply multivariate analysis methods to analyze the interaction between HA and water molecules to further
clarify the material properties of HA form the basis for monitoring its process of binding water in the body. This paper briefly
reviews important knowledge concerning the relationship between HA and water, and explains our past and ongoing related
research in this field.

Keywords:

hyaluronic acid, water, aquaphotomics, spectroscopy