Asian Journal of Complementary and Alternative Medicine

Asian Journal of Complementary and Alternative Medicine

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Research Progress on the Mechanism of Action of Danggui-Shaoyao-San Polysaccharide on Some Complications of Type II Diabetes Mellitus: A Review

Chaoqiong Yuan*, Xin Fu and Wenting Yu

College of Pharmacy, Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China


Type II diabetes mellitus (T2DM) is a group of metabolic diseases characterized by hyperglycemia, and it will cause a variety of complications. Through the research on Danggui-Shaoyao-San (DSS), scholars found that it has an active role in the treatment of diabetes and some complications. Danggui-Shaoyao-San polysaccharide (P-DSS) is the main component of Danggui-Shaoyao-San. P-DSS can participate in the physiological regulation of oxidative stress, anti-inflammatory, glucose and lipid metabolism, endoplasmic reticulum stress, bile acid metabolism and iron metabolism, especially bile acid can effectively regulate the disorder of glucose and lipid metabolism in the body, which provides a new idea for the treatment of diabetes. In addition, the therapeutic effect of P-DSS on diabetic complications may also be related to cell autophagy and intestinal flora, but there is little systematic analysis on the mechanism of P-DSS in treating diabetes and its complications. Therefore, this article reviews the potential mechanism of P-DSS in treating diabetes and its complications in detail, providing a reasonable theoretical basis for further research on P-DSS in treating T2DM.

Danggui-Shaoyao-San polysaccharide; Type II diabetes; Bile acid; Iron metabolism; Autophagy; Signal pathway
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