Hepatoprotective Acitivity of a Polyherbal Formaltion: A histological study.
Department of Pharmacology, B.R..Nahata College of Pharmacy, Mhow-Neemach Road, Mandsaur, Madhya Pradesh, 458001, India
The present study explores the hepatoprotective mechanism of a polyherbal preparation. Initially the polyherbal preparation was prepared by extracting the three herbs were choosen as Glycyrrhiza glabra, Clerodendrum serratum and Allium cepa with hydroalcoholic (50:50) solvent and further combined it to prepare a polyherbal preparation (F1). Further F1 at 200 and 400 mg/Kg were evaluated for acute toxicity and hepatoprotective activity in comparison with Silymarin as standard against Ethanol and Galactosamine induced liver toxicity in albino wistar rats and mice. Parameters like AST, ALT, Bilirubin, TBARS, Lipid peroxidation, ALP, GGTP and GSH were assessed. These biochemical observations were supplemented by the histopathological examination of liver sections. Experimental data suggested that the treatment with F1 protects the liver damage to a significant level from Ethanol and Galactosamine hepatotoxicity. From these results it may be concluded that the preparation significantly showed a dose dependent hepatoprotective effect.
Ethanol; Galatosamine; polyherbal preparation (F1); Silymarin hepatoprotection.