Evaluation of in vivo wound healing and anti-inflammatory activity of 80% methanolic extract of the leaves of B. antidysentrica J. F. Mill (Simaroubaceae) in mice
Zenaw Tessema1, Eyasu Makonnen2, Asfaw Debella3, Desalegn Yibeltal4 and Yalew Molla5
1Department of Pharmacy, College of Health Sciences, Debre Markos University, P. O. Box, 269, Debre Markos, Ethiopia.
2Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Addis Ababa University, P. O. Box, 1176, Addis Ababa, Ethiopia,
3Traditional and Modern Medicine Research Directorate, Ethiopian Public Health Institute.P.O.Box, 1242, Addis Ababa, Ethiopia.
4Department of Pharmacy, College of Health Sciences, Debre Markos University, P. O. Box, 269, Debre Markos, Ethiopia.
Objective: The purpose of this study was to evaluate the wound healing and anti-inflammatory activities of the crude extract of the leaves of B. antidysentrica J. F. Mill.
Results: Both 2% and 4% crude extract revealed significant wound healing activity compared with negative control as evidenced by an increase in the percent of wound contraction (p < 0.01) and a decrease in epithelization period (p<0.05). In addition, both 2% and 4% extract ointments resulted in a significant increase in tensile strength (p < 0.01) compared with negative control. Hundred, two hundred and four hundred mg/kg extracts of the leaves exhibited a higher anti-inflammatory effect on the 3rd (P<0.05) and 4th hour (P<0.001) as compared to the negative control.
B. antidysentrica J. F. Mill, wound healing, anti-inflammatory, excision, incision