Effect aqueous extract of Bougainvillea glabra choisy on Cutaneous Wound healing in Diabetic Rats
Rupesh Soni1, N. M. Mehta1, Rahul Trivedi2, D. N. Srivastava2
1 Faculty of Pharmaceutical Sciences, Jodhpur National University, Jodhpur-342003 (Rajasthan)
2. Department of Pharmacology & Toxicology, B. R. Nahata College of Pharmacy, Mandsaur-458001 (Madhya Pradesh)
Patients with diabetes often have wounds that are difficult to heal. The initial barrier to healing is an increased blood glucose level, which causes the cell walls to become rigid, impairing blood flow through the critical area at the wound surface. The aqueous extract of Bougainvillea glabra choisy leaves was evaluated for its wound healing activity in alloxan induced diabetic rats. There are three models excision, incision & deadspace wound models were used to study the wound repair and regeneration in normal and diabetic rats. The aqueous extract of Bougainvillea glabra choisy leaves (100mg/kg/day for 10 days) was evaluated for its wound healing activity in alloxan induced diabetic rats using excision and dead space wound models. Extract treated animal’s exhibit 77% reduction in wound area and found to epithelize faster as compared to controls. The wet and dry granulation tissue weight and Hydroxyproline tissue content increased with increase in tensile strength of extract treated rats.. The aqueous extract of Bougainvillea glabra choisy leaves treatment showed marked effect on wound healing in normal and diabetic rats. It can be a suitable part of treatment procedure of non healing diabetic and normal wounds.
Diabetes, Hydroxyproline, Tensile strength Wound healing