Asian Journal of Complementary and Alternative Medicine

Asian Journal of Complementary and Alternative Medicine

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Consumption of Sun-Exposed Oyster Mushrooms Help Patients Fight Tuberculosis

Tibebeselassie Seyoum Keflie1, Aregash Samuel2, Ashagrie Zewdu Woldegiorgis3, Christine Lambert4, Donatus Nohr4, Hans Konrad Biesalski4

170599 Stuttgart. Former at Institute of Nutritional Science, University of Hohenheim, Stuttgart, Germany.
2Ethiopian Public Health Institute, Addis Abeba, Ethiopia
3Centre for Food Science and Nutrition, College of Natural Sciences, Addis Ababa University, Addis Abeba, Ethiopia
4Institute of Nutritional Science, University of Hohenheim, Stuttgart, Germany


Introduction: Tuberculosis (TB) is an airborne infectious disease that usually affects the lungs leading to severe coughing, fever, and chest pains.

Objective: This study aimed to assess the effects of consuming sun-exposed mushrooms on the treatment outcomes of TB

Methods: Participants were TB patients and categorized into block-1 (32) and block-2 (32) based on their willingness to consume sandwich bread containing sun-exposed oyster mushrooms. Blood and sputum samples were taken at the beginning (Day 0) and end of the study (4th month). Assays of 25-hydroxy (OH) D, cytokines, LL-37, and CRP were performed using Enzyme Linked-Immunosorbent Assay (ELISA) technique, and mycobacterial cultures were performed using Löwenstein Jensen media. A p-value less than 0.05 was considered significant.

Results: Consumption of the sandwich bread induced a 27.8% increase in the mean serum 25(OH)D level with 35.5% and 32.3% reduction in the proportion of vitamin D deficiency (VDD) and insufficiency (VDI), respectively. There were progressive changes in TB score (mean ± SD of 2.6 ± 1.8; 95% CI of 1.95 to 3.17; p<0.001) and Karnofsky performance status scale (80.3 ± 6.9%, p < 0.001) with significant improvements in IFN-g and LL-37 levels (p<0.05).

Conclusion: Consumption of sun-exposed oyster mushrooms effectively improved the deficiencies of vitamin D in TB patients. The accelerated improvements on the clinical and immunological outcomes give us a clue that sun-exposed oyster mushrooms could serve as a potential, safe, easily available, and affordable adjunctive treatment and help patients fight TB.

Sun-exposure; Mushrooms; Vitamin D; Tuberculosis; Treatment outcomes
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